DYNLT3 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	CYBB	cytochrome b-245 beta chain	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation	Dextromethorphan	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
Novel	FOS	Fos proto-oncogene, AP-1 transcription factor subunit	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Pseudoephedrine Nadroparin
Novel	IFITM1	interferon induced transmembrane protein 1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon alpha/beta signaling
Novel	UIMC1	ubiquitin interaction motif containing 1	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
	C2orf15	chromosome 2 open reading frame 15
	CCL28	C-C motif chemokine ligand 28	Chemokine receptors bind chemokines G alpha (i) signalling events
	CD5	CD5 molecule
	DYNC1I1	dynein cytoplasmic 1 intermediate chain 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
	DYNC1I2	dynein cytoplasmic 1 intermediate chain 2	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
	DYNLT1	dynein light chain Tctex-type 1	Neutrophil degranulation
	NIF3L1	NGG1 interacting factor 3 like 1
	PMS1	PMS1 homolog 1, mismatch repair system component
	PVR	PVR cell adhesion molecule	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Nectin/Necl trans heterodimerization	Sphingosine Myristic acid
	TESC	tescalcin
	VDAC1	voltage dependent anion channel 1	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Pyruvate metabolism Mitochondrial calcium ion transport	Aluminium monostearate Cannabidiol Medical Cannabis Nabiximols
	ZC3H14	zinc finger CCCH-type containing 14

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