DYNLT1 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ACAT2	acetyl-CoA acetyltransferase 2	Cholesterol biosynthesis	S-Hydroxycysteine Coenzyme A
Novel	CRHBP	corticotropin releasing hormone binding protein	Class B/2 (Secretin family receptors)
Novel	ERO1A	endoplasmic reticulum oxidoreductase 1 alpha	Insulin processing Detoxification of Reactive Oxygen Species
Novel	PRKN	parkin RBR E3 ubiquitin protein ligase	PINK1-PRKN Mediated Mitophagy Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation		Parkinson's disease (PD)
Novel	RPS6KA2	ribosomal protein S6 kinase A2	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Novel	SYNJ2	synaptojanin 2	Synthesis of PIPs at the plasma membrane Clathrin-mediated endocytosis
Novel	TMEM143	transmembrane protein 143
	ACOX2	acyl-CoA oxidase 2	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Beta-oxidation of pristanoyl-CoA Peroxisomal protein import Peroxisomal protein import
	ACTN1	actinin alpha 1	Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Human calcitonin Copper
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form	Alzheimer's disease (AD)
	ARID4B	AT-rich interaction domain 4B	HDACs deacetylate histones NoRC negatively regulates rRNA expression Potential therapeutics for SARS
	BAG3	BAG cochaperone 3	Regulation of HSF1-mediated heat shock response
	BMPR2	bone morphogenetic protein receptor type 2	Signaling by BMP	Dibotermin alfa Fostamatinib
	CCDC68	coiled-coil domain containing 68
	DDX54	DEAD-box helicase 54
	DHX33	DEAH-box helicase 33
	DNAJA2	DnaJ heat shock protein family (Hsp40) member A2	HSP90 chaperone cycle for steroid hormone receptors (SHR)
	DOC2A	double C2 domain alpha
	DOC2B	double C2 domain beta
	DVL1	dishevelled segment polarity protein 1	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping

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