CDK5RAP2 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	MRRF	mitochondrial ribosome recycling factor	Mitochondrial translation termination
Novel	PHF19	PHD finger protein 19	PRC2 methylates histones and DNA
	ABCA2	ATP binding cassette subfamily A member 2	ABC transporters in lipid homeostasis
	CDK5	cyclin dependent kinase 5	DARPP-32 events CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription Activated NTRK2 signals through CDK5 Factors involved in megakaryocyte development and platelet production	Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
	CDK5R1	cyclin dependent kinase 5 regulatory subunit 1	CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5	Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
	CLIP4	CAP-Gly domain containing linker protein family member 4
	CRMP1	collapsin response mediator protein 1	CRMPs in Sema3A signaling
	EEF1G	eukaryotic translation elongation factor 1 gamma	Eukaryotic Translation Elongation
	ERG28	ergosterol biosynthesis 28 homolog
	FBXO25	F-box protein 25
	HAP1	huntingtin associated protein 1
	KAT5	lysine acetyltransferase 5	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression	Coenzyme A S-Acetyl-Cysteine
	LUC7L2	LUC7 like 2, pre-mRNA splicing factor
	MAGEH1	MAGE family member H1
	MAPRE1	microtubule associated protein RP/EB family member 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
	NEFL	neurofilament light	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
	PCBD1	pterin-4 alpha-carbinolamine dehydratase 1	Phenylalanine metabolism	L-erythro-7,8-dihydrobiopterin	Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
	PTN	pleiotrophin
	RBM48	RNA binding motif protein 48
	REPS2	RALBP1 associated Eps domain containing 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

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