AP2M1 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	CKS1B	CDC28 protein kinase regulatory subunit 1B	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1	Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
Novel	CRIP1	cysteine rich protein 1
Novel	DNAJB11	DnaJ heat shock protein family (Hsp40) member B11	XBP1(S) activates chaperone genes
Novel	EIF4G1	eukaryotic translation initiation factor 4 gamma 1	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Novel	ETV5	ETS variant transcription factor 5			Prostate cancer
Novel	FGF12	fibroblast growth factor 12	Phase 0 - rapid depolarisation
Novel	IL1RAP	interleukin 1 receptor accessory protein
Novel	JADE1	jade family PHD finger 1	HATs acetylate histones
Novel	LPP	LIM domain containing preferred translocation partner in lipoma
Novel	XPA	XPA, DNA damage recognition and repair factor	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
	ADRA1B	adrenoceptor alpha 1B	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events	Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Amitriptyline Olanzapine Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Prochlorperazine Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Modafinil Fenoldopam Dobutamine Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Mephentermine Methotrimeprazine Dextroamphetamine Dextroamphetamine Phendimetrazine Periciazine Acepromazine Thioproperazine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Pizotifen Silodosin Ocaperidone Droxidopa Xylometazoline Perospirone Brexpiprazole Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
	AGTR1	angiotensin II receptor type 1	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan	Renal tubular dysgenesis
	AP2B1	adaptor related protein complex 2 subunit beta 1	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
	AQP4	aquaporin 4	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
	ARRB2	arrestin beta 2	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants
	ATXN1L	ataxin 1 like
	BDKRB2	bradykinin receptor B2	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Anatibant Icatibant Labradimil
	C1orf35	chromosome 1 open reading frame 35	Neutrophil degranulation
	CACNA1A	calcium voltage-gated channel subunit alpha1 A	Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Ergocalciferol Enflurane Phenytoin Spironolactone Magnesium sulfate Verapamil Levomenthol Loperamide Bepridil Ziconotide Dotarizine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin	Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
	CD22	CD22 molecule	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Epratuzumab Inotuzumab ozogamicin Moxetumomab Pasudotox

Search Results for: AP2M1