TLE5 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HHEX	hematopoietically expressed homeobox			Type II diabetes mellitus
HMGB1	high mobility group box 1	Apoptosis induced DNA fragmentation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Chloroquine Ethyl pyruvate
HNF1A	HNF1 homeobox A	Regulation of gene expression in beta cells	D-norleucine	Maturity onset diabetes of the young (MODY)
HNRNPF	heterogeneous nuclear ribonucleoprotein F	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Phenethyl Isothiocyanate
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
HNRNPK	heterogeneous nuclear ribonucleoprotein K	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events	Artenimol Phenethyl Isothiocyanate
HNRNPLL	heterogeneous nuclear ribonucleoprotein L like
HOMEZ	homeobox and leucine zipper encoding
HOXA1	homeobox A1	Activation of anterior HOX genes in hindbrain development during early embryogenesis		Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome
HOXB5	homeobox B5
HOXC8	homeobox C8
HOXC9	homeobox C9
IKZF3	IKAROS family zinc finger 3
INO80B	INO80 complex subunit B	UCH proteinases DNA Damage Recognition in GG-NER
INO80E	INO80 complex subunit E	UCH proteinases DNA Damage Recognition in GG-NER
INPP5J	inositol polyphosphate-5-phosphatase J	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol
IRX2	iroquois homeobox 2
IRX6	iroquois homeobox 6
KANK2	KN motif and ankyrin repeat domains 2
KDM1A	lysine demethylase 1A	HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production

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