TLE5 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
DDX6	DEAD-box helicase 6	mRNA decay by 5' to 3' exoribonuclease	D-tartaric acid
DGCR6	DiGeorge syndrome critical region gene 6
DIP2A	disco interacting protein 2 homolog A
DMRT2	doublesex and mab-3 related transcription factor 2
DMRT3	doublesex and mab-3 related transcription factor 3
DMRTB1	DMRT like family B with proline rich C-terminal 1
DNMT3L	DNA methyltransferase 3 like	DNA methylation
DOK6	docking protein 6	RET signaling
DVL2	dishevelled segment polarity protein 2	TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
DVL3	dishevelled segment polarity protein 3	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
DYDC1	DPY30 domain containing 1
EAF1	ELL associated factor 1	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
EAF2	ELL associated factor 2	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
EFEMP2	EGF containing fibulin extracellular matrix protein 2	Molecules associated with elastic fibres Molecules associated with elastic fibres		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
EFHC1	EF-hand domain containing 1			Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
EIF1AD	eukaryotic translation initiation factor 1A domain containing
EIF4E2	eukaryotic translation initiation factor 4E family member 2	ISG15 antiviral mechanism
ERF	ETS2 repressor factor	Oncogene Induced Senescence Oncogene Induced Senescence
EXOSC5	exosome component 5	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
EYA2	EYA transcriptional coactivator and phosphatase 2	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

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