EP300 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CXCL8	C-X-C motif chemokine ligand 8	Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	ABT-510 MDX-018 Rivanicline Tapinarof
CXXC1	CXXC finger protein 1	XBP1(S) activates chaperone genes
DAO	D-amino acid oxidase	Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import	3,4-Dihydro-2h-Pyrrolium-5-Carboxylate Imino-Tryptophan Flavin adenine dinucleotide D-Tryptophan Flavin-adenine dinucleotide-N5-isobutyl ketone Benzoic acid Anthranilic acid (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
DBP	D-box binding PAR bZIP transcription factor	BMAL1:CLOCK,NPAS2 activates circadian gene expression
DDIT3	DNA damage inducible transcript 3	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency		Myxoid liposarcoma
DDX24	DEAD-box helicase 24
DDX5	DEAD-box helicase 5	SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome	Artenimol	Prostate cancer
DECR2	2,4-dienoyl-CoA reductase 2	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
DEK	DEK proto-oncogene	B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
DTX1	deltex E3 ubiquitin ligase 1	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
DUX4	double homeobox 4
E2F1	E2F transcription factor 1	Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDC6 association with the ORC:origin complex G2 Phase Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
E2F5	E2F transcription factor 5	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	Eukaryotic Translation Elongation Eukaryotic Translation Elongation Peptide chain elongation HSF1 activation Neutrophil degranulation Protein methylation Chaperone Mediated Autophagy	Zinc Guanosine-5'-Diphosphate Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
EEF2	eukaryotic translation elongation factor 2	Peptide chain elongation Peptide chain elongation Uptake and function of diphtheria toxin Synthesis of diphthamide-EEF2 Synthesis of diphthamide-EEF2 Neutrophil degranulation Protein methylation	Adenosine-5-Diphosphoribose Diphthamide Guanosine-5'-Diphosphate N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Esketamine Moxetumomab Pasudotox
EGR1	early growth response 1	Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription NGF-stimulated transcription Interferon alpha/beta signaling
EID1	EP300 interacting inhibitor of differentiation 1
EID2	EP300 interacting inhibitor of differentiation 2
ELF3	E74 like ETS transcription factor 3	Pre-NOTCH Transcription and Translation
ELK1	ETS transcription factor ELK1	ERK/MAPK targets NGF-stimulated transcription HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling

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