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STX11 |
syntaxin 11 |
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- Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
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TANK |
TRAF family member associated NFKB activator |
- TICAM1-dependent activation of IRF3/IRF7
- TRAF6 mediated IRF7 activation
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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TICAM1 |
toll like receptor adaptor molecule 1 |
- Caspase activation via Death Receptors in the presence of ligand
- MyD88-independent TLR4 cascade
- Toll Like Receptor 3 (TLR3) Cascade
- TICAM1, RIP1-mediated IKK complex recruitment
- RIP-mediated NFkB activation via ZBP1
- TRIF-mediated programmed cell death
- TICAM1 deficiency - HSE
- TRAF3 deficiency - HSE
- TLR3-mediated TICAM1-dependent programmed cell death
- TICAM1-dependent activation of IRF3/IRF7
- TICAM1,TRAF6-dependent induction of TAK1 complex
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- IKK complex recruitment mediated by RIP1
- TRAF6-mediated induction of TAK1 complex within TLR4 complex
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
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TRAF2 |
TNF receptor associated factor 2 |
- Caspase activation via Death Receptors in the presence of ligand
- Regulation by c-FLIP
- RIPK1-mediated regulated necrosis
- CASP8 activity is inhibited
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- TNFR2 non-canonical NF-kB pathway
- Regulation of necroptotic cell death
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
- Ub-specific processing proteases
- Dimerization of procaspase-8
- TNF signaling
- TRAF6 mediated IRF7 activation
- TRAF6 mediated NF-kB activation
- TRAF6 mediated NF-kB activation
- Defective RIPK1-mediated regulated necrosis
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TRAF3 |
TNF receptor associated factor 3 |
- TRAF3 deficiency - HSE
- TNFR2 non-canonical NF-kB pathway
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
- Ovarian tumor domain proteases
- TICAM1-dependent activation of IRF3/IRF7
- TRAF3-dependent IRF activation pathway
- Negative regulators of DDX58/IFIH1 signaling
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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TRAF3IP2 |
TRAF3 interacting protein 2 |
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TRAF5 |
TNF receptor associated factor 5 |
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TRIM21 |
tripartite motif containing 21 |
- STING mediated induction of host immune responses
- Regulation of innate immune responses to cytosolic DNA
- Interferon gamma signaling
- Antigen processing: Ubiquitination & Proteasome degradation
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TRIM27 |
tripartite motif containing 27 |
- SUMOylation of ubiquitinylation proteins
- Regulation of PTEN stability and activity
- Suppression of apoptosis
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TXLNG |
taxilin gamma |
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XIAP |
X-linked inhibitor of apoptosis |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- SMAC, XIAP-regulated apoptotic response
- Deactivation of the beta-catenin transactivating complex
- RIPK1-mediated regulated necrosis
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Regulation of necroptotic cell death
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Regulation of the apoptosome activity
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- 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
- Dequalinium
- N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
- AEG35156
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- Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
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