STOM - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HMOX2	heme oxygenase 2	Heme degradation Neutrophil degranulation Iron uptake and transport	NADH Stannsoporfin
KCNK1	potassium two pore domain channel subfamily K member 1	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential	Ibutilide Quinidine Quinidine barbiturate
KTN1	kinectin 1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
LANCL1	LanC like 1
LNPEP	leucyl and cystinyl aminopeptidase	Endosomal/Vacuolar pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane Antigen processing: Ubiquitination & Proteasome degradation
MGLL	monoglyceride lipase	Acyl chain remodeling of DAG and TAG Triglyceride catabolism Arachidonate production from DAG
MMP14	matrix metallopeptidase 14	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases	Marimastat
NKG7	natural killer cell granule protein 7
ORMDL1	ORMDL sphingolipid biosynthesis regulator 1	Sphingolipid de novo biosynthesis
PEDS1-UBE2V1	PEDS1-UBE2V1 readthrough	NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
PEMT	phosphatidylethanolamine N-methyltransferase	Synthesis of PC
PGA4	pepsinogen A4	Surfactant metabolism
PMP22	peripheral myelin protein 22	EGR2 and SOX10-mediated initiation of Schwann cell myelination		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
PTCH1	patched 1	Class B/2 (Secretin family receptors) Hedgehog 'off' state Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Hedgehog 'on' state Activation of SMO		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome Holoprosencephaly (HPE) Basal cell carcinoma
RPL13A	ribosomal protein L13a	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	(S)-3-phenyllactic acid Anisomycin Puromycin
RPRM	reprimo, TP53 dependent G2 arrest mediator homolog
RTP2	receptor transporter protein 2	Olfactory Signaling Pathway
RUVBL1	RuvB like AAA ATPase 1	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones UCH proteinases Ub-specific processing proteases DNA Damage Recognition in GG-NER Deposition of new CENPA-containing nucleosomes at the centromere
RUVBL2	RuvB like AAA ATPase 2	Telomere Extension By Telomerase HATs acetylate histones	Quercetin
SCD	stearoyl-CoA desaturase	Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis

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