RHOA - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ARHGEF15	Rho guanine nucleotide exchange factor 15	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
ARHGEF17	Rho guanine nucleotide exchange factor 17	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
ARHGEF18	Rho/Rac guanine nucleotide exchange factor 18	NRAGE signals death through JNK Rho GTPase cycle TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G alpha (12/13) signalling events
ARHGEF19	Rho guanine nucleotide exchange factor 19	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
ARHGEF25	Rho guanine nucleotide exchange factor 25	G alpha (q) signalling events
ARHGEF28	Rho guanine nucleotide exchange factor 28	EPHB-mediated forward signaling
ARHGEF3	Rho guanine nucleotide exchange factor 3	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
ARHGEF4	Rho guanine nucleotide exchange factor 4	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
ARHGEF5	Rho guanine nucleotide exchange factor 5	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
ARNTL	aryl hydrocarbon receptor nuclear translocator like	BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression Circadian Clock
BCR	BCR activator of RhoGEF and GTPase	Signaling by cytosolic FGFR1 fusion mutants Rho GTPase cycle Signaling by FGFR1 in disease	Imatinib Dasatinib Bosutinib Ponatinib	Chronic myeloid leukemia (CML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
BIRC2	baculoviral IAP repeat containing 2	Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
CAV1	caveolin 1	Triglyceride catabolism eNOS activation NOSTRIN mediated eNOS trafficking Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling FOXO-mediated transcription of cell cycle genes		Congenital generalized lipodystrophy (CGL)
CIT	citron rho-interacting serine/threonine kinase	RHO GTPases activate CIT RHO GTPases activate CIT	Fostamatinib
CLOCK	clock circadian regulator	BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression HATs acetylate histones Circadian Clock
CNKSR1	connector enhancer of kinase suppressor of Ras 1	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
CNTNAP1	contactin associated protein 1	Neurofascin interactions
DAAM1	dishevelled associated activator of morphogenesis 1	PCP/CE pathway RHO GTPases Activate Formins
DCUN1D1	defective in cullin neddylation 1 domain containing 1	Neddylation

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