NUP62 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
IDH1	isocitrate dehydrogenase (NADP(+)) 1	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import	Isocitric Acid Nicotinamide adenine dinucleotide phosphate Ivosidenib
IFT20	intraflagellar transport 20	Intraflagellar transport Intraflagellar transport
IK	IK cytokine
IKBIP	IKBKB interacting protein
IPO5	importin 5	vRNP Assembly
ISCU	iron-sulfur cluster assembly enzyme
KANSL1	KAT8 regulatory NSL complex subunit 1	HATs acetylate histones
KIFC3	kinesin family member C3
KLHL32	kelch like family member 32
KPNA1	karyopherin subunit alpha 1	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production
KPNA2	karyopherin subunit alpha 2	CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression
KPNB1	karyopherin subunit beta 1	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production
KRT1	keratin 1	Neutrophil degranulation Keratinization Formation of the cornified envelope	Zinc Copper Zinc acetate	Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
KRT20	keratin 20	Keratinization Formation of the cornified envelope
KRT3	keratin 3	Keratinization Formation of the cornified envelope		Meesmann corneal dystrophy
KRT6A	keratin 6A	Keratinization Formation of the cornified envelope	Zinc Zinc acetate	Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
KRT6B	keratin 6B	Keratinization Formation of the cornified envelope		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
KRT75	keratin 75	Keratinization Formation of the cornified envelope		Pseudofolliculitis barbae
LMO2	LIM domain only 2	RUNX1 regulates transcription of genes involved in differentiation of HSCs		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
LNX1	ligand of numb-protein X 1	Antigen processing: Ubiquitination & Proteasome degradation

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