ITGB1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ITGA3	integrin subunit alpha 3	Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions MET activates PTK2 signaling
ITGA4	integrin subunit alpha 4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration Potential therapeutics for SARS	Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab MK-0668
ITGA5	integrin subunit alpha 5	Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration	Resveratrol
ITGA6	integrin subunit alpha 6	Assembly of collagen fibrils and other multimeric structures Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions Type I hemidesmosome assembly		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
ITGA8	integrin subunit alpha 8	Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans
ITGA9	integrin subunit alpha 9	Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans Signal transduction by L1		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
ITGAV	integrin subunit alpha V	Cross-presentation of particulate exogenous antigens (phagosomes) Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Syndecan interactions Syndecan interactions ECM proteoglycans VEGFA-VEGFR2 Pathway Signal transduction by L1 Neutrophil degranulation	Antithymocyte immunoglobulin (rabbit) Levothyroxine
ITGB1BP1	integrin subunit beta 1 binding protein 1
ITGB1BP2	integrin subunit beta 1 binding protein 2
LAMA1	laminin subunit alpha 1	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions MET activates PTK2 signaling	Lanoteplase
LAMTOR5	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
LGALS1	galectin 1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Mercaptoethanol Thiodigalactoside 1,4-Dithiothreitol Artenimol
LGALS3BP	galectin 3 binding protein	Platelet degranulation
LGALS8	galectin 8
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	Oxidative Stress Induced Senescence	Fostamatinib
MET	MET proto-oncogene, receptor tyrosine kinase	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D mediated inhibition of cell attachment and migration RAF/MAP kinase cascade MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 MECP2 regulates neuronal receptors and channels	K-252a SGX-523 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol AMG-208 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Crizotinib Cabozantinib Capmatinib Fostamatinib Tivantinib Brigatinib Amuvatinib	Renal cell carcinoma Cholangiocarcinoma Gastric cancer
NCKIPSD	NCK interacting protein with SH3 domain	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
NF2	neurofibromin 2	Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs		Malignant pleural mesothelioma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
NGF	nerve growth factor	PLC-gamma1 signalling Signalling to RAS NGF processing NGF processing Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling PI3K/AKT activation PI3K/AKT activation Signalling to STAT3 NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	Clenbuterol RI 624 Polaprezinc
NME1	NME/NM23 nucleoside diphosphate kinase 1	Interconversion of nucleotide di- and triphosphates	Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form

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