GCC1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
KIAA1217	KIAA1217
KIF5B	kinesin family member 5B	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
LCA5	lebercilin LCA5			Leber congenital amaurosis (LCR)
LZTS2	leucine zipper tumor suppressor 2
MCRS1	microspherule protein 1	HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER
MED4	mediator complex subunit 4	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
MEOX1	mesenchyme homeobox 1
MID2	midline 2
NAB2	NGFI-A binding protein 2	NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
NAV1	neuron navigator 1
NECAB2	N-terminal EF-hand calcium binding protein 2
NINL	ninein like	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
OIP5	Opa interacting protein 5	Deposition of new CENPA-containing nucleosomes at the centromere
PAK5	p21 (RAC1) activated kinase 5	Activation of RAC1	Fostamatinib
PPP1R18	protein phosphatase 1 regulatory subunit 18
PPP1R27	protein phosphatase 1 regulatory subunit 27
PRPF18	pre-mRNA processing factor 18
RUNX1	RUNX family transcription factor 1	Pre-NOTCH Transcription and Translation Organic cation transport RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis		Chronic myeloid leukemia (CML) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Acute myeloid leukemia (AML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SPOP	speckle type BTB/POZ protein	Hedgehog 'on' state

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