VPS11 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
RILP	Rab interacting lysosomal protein	MHC class II antigen presentation
RNF181	ring finger protein 181	E3 ubiquitin ligases ubiquitinate target proteins
STX1A	syntaxin 1A	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (botC) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
STX6	syntaxin 6	Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
STX7	syntaxin 7
STX8	syntaxin 8
TFAP2B	transcription factor AP-2 beta	SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors		Char syndrome
TRIM32	tripartite motif containing 32	Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation		Bardet-Biedl syndrome (BBS)
TSG101	tumor susceptibility 101	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
UBE2D2	ubiquitin conjugating enzyme E2 D2	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Antigen processing: Ubiquitination & Proteasome degradation	(R,R)-2,3-Butanediol
UBE2L3	ubiquitin conjugating enzyme E2 L3	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
UBE2U	ubiquitin conjugating enzyme E2 U	Antigen processing: Ubiquitination & Proteasome degradation
UVRAG	UV radiation resistance associated	Macroautophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
VPS16	VPS16 core subunit of CORVET and HOPS complexes
VPS18	VPS18 core subunit of CORVET and HOPS complexes
VPS33A	VPS33A core subunit of CORVET and HOPS complexes
VPS39	VPS39 subunit of HOPS complex
VPS45	vacuolar protein sorting 45 homolog	Intra-Golgi traffic Factors involved in megakaryocyte development and platelet production

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