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IRF5 |
interferon regulatory factor 5 |
- Interferon gamma signaling
- Interferon alpha/beta signaling
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IRF7 |
interferon regulatory factor 7 |
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Interferon gamma signaling
- TICAM1-dependent activation of IRF3/IRF7
- Interferon alpha/beta signaling
- TRAF3-dependent IRF activation pathway
- TRAF6 mediated IRF7 activation
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
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MAP1LC3B |
microtubule associated protein 1 light chain 3 beta |
- Macroautophagy
- PINK1-PRKN Mediated Mitophagy
- TBC/RABGAPs
- Receptor Mediated Mitophagy
- Pexophagy
- Translation of Replicase and Assembly of the Replication Transcription Complex
- Translation of Replicase and Assembly of the Replication Transcription Complex
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MAVS |
mitochondrial antiviral signaling protein |
- DDX58/IFIH1-mediated induction of interferon-alpha/beta
- Ovarian tumor domain proteases
- TRAF3-dependent IRF activation pathway
- TRAF6 mediated IRF7 activation
- TRAF6 mediated NF-kB activation
- TRAF6 mediated NF-kB activation
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- Negative regulators of DDX58/IFIH1 signaling
- Negative regulators of DDX58/IFIH1 signaling
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MBP |
myelin basic protein |
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
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MIB2 |
MIB E3 ubiquitin protein ligase 2 |
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- Antigen processing: Ubiquitination & Proteasome degradation
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MTPAP |
mitochondrial poly(A) polymerase |
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NCK1 |
NCK adaptor protein 1 |
- Downstream signal transduction
- Generation of second messenger molecules
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- Nephrin family interactions
- DCC mediated attractive signaling
- DCC mediated attractive signaling
- Activation of RAC1
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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NEDD4 |
NEDD4 E3 ubiquitin protein ligase |
- ISG15 antiviral mechanism
- Downregulation of ERBB4 signaling
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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NFKBIA |
NFKB inhibitor alpha |
- Activation of NF-kappaB in B cells
- RIP-mediated NFkB activation via ZBP1
- Downstream TCR signaling
- NF-kB is activated and signals survival
- FCERI mediated NF-kB activation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- SUMOylation of immune response proteins
- IkBA variant leads to EDA-ID
- CLEC7A (Dectin-1) signaling
- Ub-specific processing proteases
- Interleukin-1 signaling
- TRAF6 mediated NF-kB activation
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- Acetylsalicylic acid
- Bardoxolone methyl
- Astaxanthin
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- Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
- Hodgkin lymphoma
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PROS1 |
protein S |
- Platelet degranulation
- Intrinsic Pathway of Fibrin Clot Formation
- Common Pathway of Fibrin Clot Formation
- Gamma-carboxylation of protein precursors
- Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
- Removal of aminoterminal propeptides from gamma-carboxylated proteins
- Cell surface interactions at the vascular wall
- Regulation of Complement cascade
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- Drotrecogin alfa
- Menadione
- Sodium tetradecyl sulfate
- Kappadione
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PTPRD |
protein tyrosine phosphatase receptor type D |
- Receptor-type tyrosine-protein phosphatases
- Synaptic adhesion-like molecules
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RELA |
RELA proto-oncogene, NF-kB subunit |
- Activation of NF-kappaB in B cells
- RIP-mediated NFkB activation via ZBP1
- Regulated proteolysis of p75NTR
- Downstream TCR signaling
- NF-kB is activated and signals survival
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated NF-kB activation
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- PKMTs methylate histone lysines
- Transcriptional regulation of white adipocyte differentiation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Interleukin-1 processing
- SUMOylation of immune response proteins
- IkBA variant leads to EDA-ID
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- CD209 (DC-SIGN) signaling
- CLEC7A/inflammasome pathway
- The NLRP3 inflammasome
- Transcriptional Regulation by VENTX
- Interleukin-1 signaling
- TRAF6 mediated NF-kB activation
- Purinergic signaling in leishmaniasis infection
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RIPK1 |
receptor interacting serine/threonine kinase 1 |
- Caspase activation via Death Receptors in the presence of ligand
- TICAM1, RIP1-mediated IKK complex recruitment
- RIP-mediated NFkB activation via ZBP1
- TRIF-mediated programmed cell death
- TRP channels
- Regulation by c-FLIP
- RIPK1-mediated regulated necrosis
- CASP8 activity is inhibited
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Regulation of necroptotic cell death
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Dimerization of procaspase-8
- TNF signaling
- TLR3-mediated TICAM1-dependent programmed cell death
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- IKK complex recruitment mediated by RIP1
- Potential therapeutics for SARS
- Microbial modulation of RIPK1-mediated regulated necrosis
- Defective RIPK1-mediated regulated necrosis
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RNF128 |
ring finger protein 128 |
- Ub-specific processing proteases
- Ovarian tumor domain proteases
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RPS6KB1 |
ribosomal protein S6 kinase B1 |
- mTORC1-mediated signalling
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SIKE1 |
suppressor of IKBKE 1 |
- TRAF3-dependent IRF activation pathway
- TRAF6 mediated IRF7 activation
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SMCR8 |
SMCR8-C9orf72 complex subunit |
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SMURF1 |
SMAD specific E3 ubiquitin protein ligase 1 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Asymmetric localization of PCP proteins
- Hedgehog 'on' state
- Hedgehog 'on' state
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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SQSTM1 |
sequestosome 1 |
- NRIF signals cell death from the nucleus
- p75NTR recruits signalling complexes
- NF-kB is activated and signals survival
- PINK1-PRKN Mediated Mitophagy
- Interleukin-1 signaling
- Pexophagy
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- Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
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