ITGB1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
EPS8	epidermal growth factor receptor pathway substrate 8
FBLN1	fibulin 1	Molecules associated with elastic fibres Molecules associated with elastic fibres		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
FBXO2	F-box protein 2	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
FERMT1	FERM domain containing kindlin 1			Kindler syndrome
FERMT2	FERM domain containing kindlin 2	Cell-extracellular matrix interactions
FERMT3	FERM domain containing kindlin 3	Platelet degranulation		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
FHL2	four and a half LIM domains 2	PPARA activates gene expression
FLNA	filamin A	Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	Artenimol	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia Periventricular nodular heterotopia (PVNH) FG syndrome (FGS); Opitz-Kaveggia syndrome
FLNB	filamin B	ISG15 antiviral mechanism		Spondylocarpotarsal synostosis syndrome FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome
FLT4	fms related receptor tyrosine kinase 4	VEGF binds to VEGFR leading to receptor dimerization NOTCH4 Intracellular Domain Regulates Transcription	Sorafenib Sunitinib Vatalanib TG-100801 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib Regorafenib Lenvatinib Nintedanib Fostamatinib Selpercatinib	Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
FN1	fibronectin 1	Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Extracellular matrix organization Fibronectin matrix formation Cell surface interactions at the vascular wall Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Interleukin-4 and Interleukin-13 signaling Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates PTK2 signaling Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Zinc Lanoteplase Ocriplasmin Zinc acetate Zinc chloride Zinc sulfate, unspecified form
HSPD1	heat shock protein family D (Hsp60) member 1	Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Copper	Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
HSPG2	heparan sulfate proteoglycan 2	Degradation of the extracellular matrix Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation	Palifermin	Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
IGF1R	insulin like growth factor 1 receptor	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling	Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Phosphoaminophosphonic Acid-Adenylate Ester ATL1101 XL228 rhIGFBP-3 Linsitinib Teprotumumab (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE Somatrem Insulin degludec Cixutumumab Brigatinib Mecasermin rinfabate	Malignant pleural mesothelioma Synovial sarcoma
ILK	integrin linked kinase	Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
ITGA1	integrin subunit alpha 1	Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen
ITGA10	integrin subunit alpha 10	Integrin cell surface interactions Integrin cell surface interactions CHL1 interactions Platelet Adhesion to exposed collagen
ITGA11	integrin subunit alpha 11	Integrin cell surface interactions Integrin cell surface interactions
ITGA2	integrin subunit alpha 2	Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans CHL1 interactions Platelet Adhesion to exposed collagen MET activates PTK2 signaling

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