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CLK1 |
CDC like kinase 1 |
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- Debromohymenialdisine
- CHGN111
- ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
- Fostamatinib
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CPLANE2 |
ciliogenesis and planar polarity effector 2 |
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IL1F10 |
interleukin 1 family member 10 |
- Interleukin-38 signaling
- Interleukin-36 pathway
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IMPDH1 |
inosine monophosphate dehydrogenase 1 |
- Neutrophil degranulation
- Purine ribonucleoside monophosphate biosynthesis
- Potential therapeutics for SARS
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- NADH
- Mycophenolate mofetil
- Ribavirin
- Mycophenolic acid
- Mercaptopurine
- 6-Chloropurine Riboside, 5'-Monophosphate
- VX-148
- Taribavirin
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- Leber congenital amaurosis (LCR)
- Retinitis pigmentosa (RP)
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PIAS4 |
protein inhibitor of activated STAT 4 |
- Vitamin D (calciferol) metabolism
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of DNA replication proteins
- SUMOylation of immune response proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- G2/M DNA damage checkpoint
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POU6F2 |
POU class 6 homeobox 2 |
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STAT3 |
signal transducer and activator of transcription 3 |
- Interleukin-6 signaling
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Interleukin-7 signaling
- Interleukin-7 signaling
- Signaling by SCF-KIT
- Signaling by cytosolic FGFR1 fusion mutants
- Downstream signal transduction
- Signalling to STAT3
- Senescence-Associated Secretory Phenotype (SASP)
- Signaling by Leptin
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Association of TriC/CCT with target proteins during biosynthesis
- Transcriptional regulation of pluripotent stem cells
- Interleukin-10 signaling
- Interleukin-4 and Interleukin-13 signaling
- PTK6 Activates STAT3
- PTK6 Activates STAT3
- Interleukin-20 family signaling
- MET activates STAT3
- MET activates STAT3
- Interleukin-15 signaling
- Interleukin-35 Signalling
- Interleukin-9 signaling
- Interleukin-37 signaling
- Interleukin-23 signaling
- Interleukin-23 signaling
- Interleukin-27 signaling
- Interleukin-21 signaling
- Transcriptional regulation of granulopoiesis
- Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
- Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
- Signaling by PDGFRA extracellular domain mutants
- Growth hormone receptor signaling
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- Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
- Oral cancer
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SUMO2 |
small ubiquitin like modifier 2 |
- Vitamin D (calciferol) metabolism
- SUMO is conjugated to E1 (UBA2:SAE1)
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMO is proteolytically processed
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA replication proteins
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
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SUMO4 |
small ubiquitin like modifier 4 |
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TRAF2 |
TNF receptor associated factor 2 |
- Caspase activation via Death Receptors in the presence of ligand
- Regulation by c-FLIP
- RIPK1-mediated regulated necrosis
- CASP8 activity is inhibited
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- TNFR2 non-canonical NF-kB pathway
- Regulation of necroptotic cell death
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
- Ub-specific processing proteases
- Dimerization of procaspase-8
- TNF signaling
- TRAF6 mediated IRF7 activation
- TRAF6 mediated NF-kB activation
- TRAF6 mediated NF-kB activation
- Defective RIPK1-mediated regulated necrosis
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UBQLN4 |
ubiquilin 4 |
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