EXOSC8 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
EXOSC2	exosome component 2	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC4	exosome component 4	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC5	exosome component 5	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC6	exosome component 6	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC7	exosome component 7	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC9	exosome component 9	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
FAM161B	FAM161 centrosomal protein B
FAM90A1	family with sequence similarity 90 member A1
FHOD1	formin homology 2 domain containing 1
FOXD4L1	forkhead box D4 like 1
FOXN3	forkhead box N3
FRG1	FSHD region gene 1
GEM	GTP binding protein overexpressed in skeletal muscle
HAPLN2	hyaluronan and proteoglycan link protein 2
HOXB9	homeobox B9
INCA1	inhibitor of CDK, cyclin A1 interacting protein 1
KANK2	KN motif and ankyrin repeat domains 2
KCNJ11	potassium inwardly rectifying channel subfamily J member 11	ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Defective ABCC8 can cause hypo- and hyper-glycemias	Glimepiride Ibutilide Verapamil Tolazamide Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine Butamben Isavuconazole	Type II diabetes mellitus Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
LMO4	LIM domain only 4
LNX1	ligand of numb-protein X 1	Antigen processing: Ubiquitination & Proteasome degradation

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