ECSIT - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CYP2C9	cytochrome P450 family 2 subfamily C member 9	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs	Ferroheme C Diacerein Benzbromarone
DNAJB1	DnaJ heat shock protein family (Hsp40) member B1	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
DTX2	deltex E3 ubiquitin ligase 2	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
ELAVL3	ELAV like RNA binding protein 3
EXOC6	exocyst complex component 6	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
EXOSC1	exosome component 1	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
FARSA	phenylalanyl-tRNA synthetase subunit alpha	Cytosolic tRNA aminoacylation	Phenylalanine
FBXL12	F-box and leucine rich repeat protein 12	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
FBXW4	F-box and WD repeat domain containing 4	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
GCDH	glutaryl-CoA dehydrogenase	Lysine catabolism	Flavin adenine dinucleotide S-4-Nitrobutyryl-CoA	Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GEM	GTP binding protein overexpressed in skeletal muscle
IFIT3	interferon induced protein with tetratricopeptide repeats 3	Interferon alpha/beta signaling
IFIT5	interferon induced protein with tetratricopeptide repeats 5	Interferon alpha/beta signaling
IMMT	inner membrane mitochondrial protein	Cristae formation
LONP1	lon peptidase 1, mitochondrial
LOXL4	lysyl oxidase like 4	Elastic fibre formation Crosslinking of collagen fibrils
MAGEB2	MAGE family member B2
MAST1	microtubule associated serine/threonine kinase 1		Fostamatinib
MKRN3	makorin ring finger protein 3
NFKB1	nuclear factor kappa B subunit 1	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection	Donepezil Pseudoephedrine Thalidomide Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Triflusal Glycyrrhizic acid Fish oil SC-236

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