CUL3 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CDC25A	cell division cycle 25A	Transcription of E2F targets under negative control by DREAM complex Polo-like kinase mediated events Activation of ATR in response to replication stress Ub-specific processing proteases Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
CDC34	cell division cycle 34, ubiqiutin conjugating enzyme	Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
CLK1	CDC like kinase 1		Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
COMMD1	copper metabolism domain containing 1	Neddylation
COPS5	COP9 signalosome subunit 5	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
DCUN1D2	defective in cullin neddylation 1 domain containing 2	Neddylation
DCUN1D3	defective in cullin neddylation 1 domain containing 3	Neddylation
DCUN1D4	defective in cullin neddylation 1 domain containing 4	Neddylation
DCUN1D5	defective in cullin neddylation 1 domain containing 5	Neddylation
DYRK4	dual specificity tyrosine phosphorylation regulated kinase 4
EFNB1	ephrin B1	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
ELOC	elongin C	Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
FOLR1	folate receptor alpha	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport	Folic acid Vintafolide Farletuzumab
GABARAP	GABA type A receptor-associated protein	Macroautophagy TBC/RABGAPs
GABARAPL1	GABA type A receptor associated protein like 1	Macroautophagy
GABARAPL2	GABA type A receptor associated protein like 2	Macroautophagy TBC/RABGAPs
GMCL1	germ cell-less 1, spermatogenesis associated
GPS1	G protein pathway suppressor 1	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
HLA-DMB	major histocompatibility complex, class II, DM beta	MHC class II antigen presentation
HSF2	heat shock transcription factor 2

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