COMT - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
GJB4	gap junction protein beta 4	Gap junction assembly		Erythrokeratodermia variabilis
GJB5	gap junction protein beta 5	Gap junction assembly
GLP1R	glucagon like peptide 1 receptor	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide
GPR152	G protein-coupled receptor 152
GPR161	G protein-coupled receptor 161	Hedgehog 'off' state Hedgehog 'on' state
GPR42	G protein-coupled receptor 42
HIBADH	3-hydroxyisobutyrate dehydrogenase	Branched-chain amino acid catabolism	NADH
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC) Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
KCNK5	potassium two pore domain channel subfamily K member 5	Phase 4 - resting membrane potential
KRT31	keratin 31	Keratinization Formation of the cornified envelope
KRT40	keratin 40	Keratinization Formation of the cornified envelope
KRTAP5-9	keratin associated protein 5-9	Keratinization
LITAF	lipopolysaccharide induced TNF factor			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
MFSD14B	major facilitator superfamily domain containing 14B
MTNR1A	melatonin receptor 1A	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
MYADML2	myeloid associated differentiation marker like 2
NIPAL4	NIPA like domain containing 4	Miscellaneous transport and binding events		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
OTOP3	otopetrin 3
PGAP2	post-GPI attachment to proteins 2
PLPP6	phospholipid phosphatase 6	Cholesterol biosynthesis

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