CLU - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
HSPD1	heat shock protein family D (Hsp60) member 1	Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Copper	Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
IL24	interleukin 24	Interleukin-20 family signaling
KATNA1	katanin catalytic subunit A1
KEAP1	kelch like ECH associated protein 1	Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Dimethyl fumarate
KLF11	Kruppel like factor 11			Maturity onset diabetes of the young (MODY)
KNSTRN	kinetochore localized astrin (SPAG5) binding protein
LEP	leptin	Signaling by Leptin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and deacylation of Ghrelin
LEPR	leptin receptor		Leptin Metreleptin
LIG4	DNA ligase 4	2-LTR circle formation Nonhomologous End-Joining (NHEJ)		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
LRP2	LDL receptor related protein 2	Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport	Urokinase Insulin pork Gentamicin	Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
LRP8	LDL receptor related protein 8	Platelet sensitization by LDL Retinoid metabolism and transport
LYZ	lysozyme	Neutrophil degranulation Antimicrobial peptides Amyloid fiber formation	Aspartic acid (R)-Propylene glycol 4-methyl-umbelliferyl-N-acetyl-chitobiose Sucrose Arsanilic acid 4)-N-acetyl-beta-D-glucosamine p-Toluenesulfonic acid Propyl alcohol Cu-Cyclam (S)-Aspartimide Dodecyl sulfate Triacetylchitotriose Methylumbelliferyl chitotriose UNDECA-3,7-DIENE-1,3,7,11-TETRACARBALDEHYDE	Familial amyloidosis
MAPK9	mitogen-activated protein kinase 9	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors	Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin
MDM2	MDM2 proto-oncogene	AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity	Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Choriocarcinoma Osteosarcoma Glioma Penile cancer Alveolar rhabdomyosarcoma
MMP25	matrix metallopeptidase 25	Activation of Matrix Metalloproteinases Neutrophil degranulation	Marimastat Fenofibrate Fenofibric acid
MSRB1	methionine sulfoxide reductase B1	Protein repair
PAXIP1	PAX interacting protein 1	Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ)
PLXNA4	plexin A4	Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
POLR1C	RNA polymerase I and III subunit C	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter		Treacher Collins syndrome
PON1	paraoxonase 1	Synthesis of 5-eicosatetraenoic acids	Cefazolin Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form

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