TLE5 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
SUPT5H	SPT5 homolog, DSIF elongation factor subunit	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE
TBX3	T-box transcription factor 3		Ulnar-mammary syndrome; Schinzel syndrome
TBX6	T-box transcription factor 6
TCEANC	transcription elongation factor A N-terminal and central domain containing
TCF4	transcription factor 4	Myogenesis Myogenesis	Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
TCF7L2	transcription factor 7 like 2	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Signaling by TCF7L2 mutants Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling	Type II diabetes mellitus
TEAD4	TEA domain transcription factor 4	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
TENT5B	terminal nucleotidyltransferase 5B
TEX37	testis expressed 37
TFAP2D	transcription factor AP-2 delta	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
THAP7	THAP domain containing 7
TIGD3	tigger transposable element derived 3
TMCC2	transmembrane and coiled-coil domain family 2
TNS2	tensin 2
TOX3	TOX high mobility group box family member 3
TRAF1	TNF receptor associated factor 1	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway
TRAF2	TNF receptor associated factor 2	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis
TRIB3	tribbles pseudokinase 3	PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
TRIM26	tripartite motif containing 26	Interferon gamma signaling
TRIM27	tripartite motif containing 27	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis

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