TLE5 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SIX2	SIX homeobox 2
SIX3	SIX homeobox 3			Holoprosencephaly (HPE)
SIX6	SIX homeobox 6			Anophthalmia and microphthalmia (A/M)
SKIL	SKI like proto-oncogene	Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD3	SMAD family member 3	Signaling by NODAL Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes
SMAD4	SMAD family member 4	Signaling by NODAL Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes		Colorectal cancer Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer Juvenile polyposis syndrome
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SNCAIP	synuclein alpha interacting protein	Amyloid fiber formation
SNRPA	small nuclear ribonucleoprotein polypeptide A	mRNA Splicing - Major Pathway	Malonic acid
SNRPC	small nuclear ribonucleoprotein polypeptide C	mRNA Splicing - Major Pathway
SOHLH1	spermatogenesis and oogenesis specific basic helix-loop-helix 1
SOX5	SRY-box transcription factor 5
SPATA25	spermatogenesis associated 25
SPG21	SPG21 abhydrolase domain containing, maspardin			Hereditary spastic paraplegia (SPG)
SRPK2	SRSF protein kinase 2		Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester
SSC4D	scavenger receptor cysteine rich family member with 4 domains
STK16	serine/threonine kinase 16		Fostamatinib
STX11	syntaxin 11			Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
SUFU	SUFU negative regulator of hedgehog signaling	Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome

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