GOLGA2 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
IKZF3	IKAROS family zinc finger 3
IL16	interleukin 16	Other interleukin signaling
INPP5J	inositol polyphosphate-5-phosphatase J	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol
IQCE	IQ motif containing E	Activation of SMO
IQUB	IQ motif and ubiquitin domain containing
ISCU	iron-sulfur cluster assembly enzyme
ITGB5	integrin subunit beta 5	Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction
ITPKB	inositol-trisphosphate 3-kinase B	Synthesis of IP3 and IP4 in the cytosol
ITSN2	intersectin 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
KANK2	KN motif and ankyrin repeat domains 2
KANSL1	KAT8 regulatory NSL complex subunit 1	HATs acetylate histones
KAT5	lysine acetyltransferase 5	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression	Coenzyme A S-Acetyl-Cysteine
KDM1A	lysine demethylase 1A	HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
KIAA1217	KIAA1217
KIFC3	kinesin family member C3
KRT1	keratin 1	Neutrophil degranulation Keratinization Formation of the cornified envelope	Zinc Copper Zinc acetate	Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
KRT18	keratin 18	Keratinization Formation of the cornified envelope
KRT6A	keratin 6A	Keratinization Formation of the cornified envelope	Zinc Zinc acetate	Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
KRT6B	keratin 6B	Keratinization Formation of the cornified envelope		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
KRT6C	keratin 6C	Keratinization Formation of the cornified envelope

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