PRIM2 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	GTF3C6	general transcription factor IIIC subunit 6	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Novel	RUNX2	RUNX family transcription factor 2			Cleidocranial dysplasia
	KDM1A	lysine demethylase 1A	HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
	POLA1	DNA polymerase alpha 1, catalytic subunit	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription	Cladribine Clofarabine Fludarabine Nelarabine
	POLA2	DNA polymerase alpha 2, accessory subunit	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Dacarbazine
	PRIM1	DNA primase subunit 1	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
	RECK	reversion inducing cysteine rich protein with kazal motifs	Post-translational modification: synthesis of GPI-anchored proteins
	SUV39H1	suppressor of variegation 3-9 homolog 1	PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression

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