CLU - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ADGRF4	adhesion G protein-coupled receptor F4
Novel	CBR3	carbonyl reductase 3	Phase I - Functionalization of compounds
Novel	DUSP13	dual specificity phosphatase 13
Novel	GEMIN7	gem nuclear organelle associated protein 7	snRNP Assembly
Novel	KRT12	keratin 12	Keratinization Formation of the cornified envelope	Griseofulvin Anthralin	Meesmann corneal dystrophy
Novel	NAT2	N-acetyltransferase 2	Acetylation
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form	Alzheimer's disease (AD)
	BAG6	BAG cochaperone 6	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
	C7	complement C7	Terminal pathway of complement Regulation of Complement cascade		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
	C8B	complement C8 beta chain	Terminal pathway of complement Regulation of Complement cascade	Zinc Copper Zinc acetate	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
	C9	complement C9	Terminal pathway of complement Regulation of Complement cascade	Copper	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
	CBY1	chibby family member 1, beta catenin antagonist	Deactivation of the beta-catenin transactivating complex
	CD209	CD209 molecule	CD209 (DC-SIGN) signaling Butyrophilin (BTN) family interactions
	CLUAP1	clusterin associated protein 1	Intraflagellar transport Intraflagellar transport
	CYP2E1	cytochrome P450 family 2 subfamily E member 1	Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs	Diacerein
	DISC1	DISC1 scaffold protein
	ELN	elastin	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Rofecoxib	Congenital supravalvar aortic stenosis Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
	EPPIN	epididymal peptidase inhibitor	Antimicrobial peptides
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Pseudoephedrine Nadroparin
	GRB2	growth factor receptor bound protein 2	Interleukin-15 signaling Interleukin-15 signaling STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants	Pegademase 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid

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