CHPF - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ATG9A	autophagy related 9A	Macroautophagy
Novel	CERS5	ceramide synthase 5	Sphingolipid de novo biosynthesis
Novel	GLB1L	galactosidase beta 1 like	Glycosphingolipid metabolism Keratan sulfate degradation HS-GAG degradation
Novel	ITGB2	integrin subunit beta 2	Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
Novel	NPBWR2	neuropeptides B and W receptor 2	Peptide ligand-binding receptors G alpha (i) signalling events
Novel	RAC2	Rac family small GTPase 2	GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Dextromethorphan	Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
Novel	RNF25	ring finger protein 25	Antigen processing: Ubiquitination & Proteasome degradation
Novel	TUBA4B	tubulin alpha 4b
	ARHGEF5	Rho guanine nucleotide exchange factor 5	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
	BTRC	beta-transducin repeat containing E3 ubiquitin protein ligase	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation
	EXOSC10	exosome component 10	Major pathway of rRNA processing in the nucleolus and cytosol
	EXOSC6	exosome component 6	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
	LINC00839	long intergenic non-protein coding RNA 839
	NKX3-1	NK3 homeobox 1			Prostate cancer
	PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	ISG15 antiviral mechanism RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation PI5P Regulates TP53 Acetylation Negative regulators of DDX58/IFIH1 signaling	Beta-(2-Naphthyl)-Alanine 3,6,9,12,15,18-HEXAOXAICOSANE
	PRKN	parkin RBR E3 ubiquitin protein ligase	PINK1-PRKN Mediated Mitophagy Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation		Parkinson's disease (PD)
	SKIL	SKI like proto-oncogene	Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
	SMAD9	SMAD family member 9	Signaling by BMP

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