ARF6 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ALDH5A1	aldehyde dehydrogenase 5 family member A1	Degradation of GABA	Succinic acid NADH Valproic acid Chlormerodrin	Succinic semialdehyde dehydrogenase (SSADH) deficiency; 4-Hydroxybutyric aciduria (4-HBA)
Novel	LSM7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Novel	MGAM	maltase-glucoamylase	Digestion of dietary carbohydrate Neutrophil degranulation	Acarbose Miglitol Voglibose
Novel	PRPF39	pre-mRNA processing factor 39
Novel	RPLP1	ribosomal protein lateral stalk subunit P1	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Novel	SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Novel	TOGARAM1	TOG array regulator of axonemal microtubules 1
	AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
	AP1B1	adaptor related protein complex 1 subunit beta 1	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
	AP3B1	adaptor related protein complex 3 subunit beta 1	Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF fusions		Hermansky-Pudlak syndrome (HPS)
	AP3D1	adaptor related protein complex 3 subunit delta 1
	AP3S2	adaptor related protein complex 3 subunit sigma 2
	APBB1	amyloid beta precursor protein binding family B member 1	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form	Alzheimer's disease (AD)
	ARFIP2	ADP ribosylation factor interacting protein 2	Retrograde transport at the Trans-Golgi-Network
	ARHGAP10	Rho GTPase activating protein 10	Rho GTPase cycle Regulation of PAK-2p34 activity by PS-GAP/RHG10
	ARRB1	arrestin beta 1	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants
	ARRB2	arrestin beta 2	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants
	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

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