AQR and CHRNA7

Data Source:
BioGRID (genetic interference)

		AQR	CHRNA7
Description		aquarius intron-binding spliceosomal factor	cholinergic receptor nicotinic alpha 7 subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane Postsynapse
	Molecular Function	RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding ATP Binding 3'-5' RNA Helicase Activity	Amyloid-beta Binding Ion Channel Activity Calcium Channel Activity Protein Binding Acetylcholine Receptor Activity Toxic Substance Binding Chloride Channel Regulator Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Protein Homodimerization Activity
	Biological Process	MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair	Activation Of MAPK Activity Response To Hypoxia Positive Regulation Of Protein Phosphorylation Ion Transport Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Learning Or Memory Memory Short-term Memory Positive Regulation Of Cell Population Proliferation Negative Regulation Of Tumor Necrosis Factor Production Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Positive Regulation Of Angiogenesis Synapse Organization Nervous System Process Cognition Sensory Processing Positive Regulation Of Protein Metabolic Process Excitatory Postsynaptic Potential Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Acetylcholine Receptor Signaling Pathway Dendritic Spine Organization Modulation Of Excitatory Postsynaptic Potential Dendrite Arborization Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Neuron Death Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Response To Amyloid-beta Response To Acetylcholine Regulation Of Amyloid Fibril Formation Positive Regulation Of CoA-transferase Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Drugs			Choline Nicotine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Thiopental Mecamylamine Galantamine Primidone Methylphenobarbital Ethanol Amantadine Phenobarbital Tubocurarine Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Acetylcholine Lobeline GTS-21 RPI-78M Epibatidine Cytisine Cannabidiol Encenicline Choline salicylate Medical Cannabis Nabiximols
Diseases
GWAS			Hepatocyte growth factor levels ( 25998175)
Interacting Genes		40 interacting genes: MIR1-1 MIR106A MIR106B MIR107 MIR128-2 MIR145 MIR15B MIR199A2 MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR214 MIR221 MIR222 MIR25 MIR29A MIR31 MIR34A MIR34B MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7G MIRLET7I PQBP1 RBM22 RBM4 WDR77	4 interacting genes: ADCY6 APP ATXN1 PIK3R1
Entrez ID		9716	1139
HPRD ID		12468	00339
Ensembl ID		ENSG00000021776	ENSG00000175344
Uniprot IDs		A0A024R9L1 O60306	A0A0A6YYA8 P36544
PDB IDs		4PJ3 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P	2MAW 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?