EDEM1 and PDZD11

Data Source:
HPRD (in vitro, in vivo)

		EDEM1	PDZD11
Description		ER degradation enhancing alpha-mannosidase like protein 1	PDZ domain containing 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Aggresome Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment	Extracellular Region Cytosol Cell-cell Junction Adherens Junction Basolateral Plasma Membrane Synapse Pore Complex Presynapse
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding	Protein Binding
	Biological Process	Carbohydrate Metabolic Process Ubiquitin-dependent ERAD Pathway IRE1-mediated Unfolded Protein Response Trimming Of Terminal Mannose On C Branch Protein Targeting To ER Ubiquitin-dependent Glycoprotein ERAD Pathway Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Mannose Trimming Involved In Glycoprotein ERAD Pathway	Biotin Metabolic Process Neurotransmitter Secretion Pantothenate Metabolic Process Antimicrobial Humoral Response Ion Transmembrane Transport Maintenance Of Epithelial Cell Apical/basal Polarity Pore Complex Assembly Transmembrane Transport Protein Localization To Basolateral Plasma Membrane
Pathways		XBP1(S) activates chaperone genes ER Quality Control Compartment (ERQC)	Biotin transport and metabolism Vitamin B5 (pantothenate) metabolism Transport of vitamins, nucleosides, and related molecules Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Metabolite levels ( 23823483) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Uterine fibroids ( 28836065)
Interacting Genes		1 interacting genes: CANX	5 interacting genes: ATP2B2 ATP7A MAGI2 PLEKHA5 SIGMAR1
Entrez ID		9695	51248
HPRD ID		09644	06622
Ensembl ID		ENSG00000134109	ENSG00000120509
Uniprot IDs		A0A024R2D5 Q92611	Q5EBL8
PDB IDs
Enriched GO Terms of Interacting Partners?
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