EIF4E2 and MVK

Data Source:
BioGRID (affinity chromatography technology)

		EIF4E2	MVK
Description		eukaryotic translation initiation factor 4E family member 2	mevalonate kinase
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GO Annotations	Cellular Component	P-body Cytoplasm Cytosol MRNA Cap Binding Complex Eukaryotic Translation Initiation Factor 4F Complex	Peroxisome Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding	Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Translational Initiation Negative Regulation Of Translation Gene Silencing By RNA Positive Regulation Of MiRNA Mediated Inhibition Of Translation	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Inflammatory Response
Pathways		ISG15 antiviral mechanism	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			Farnesyl thiopyrophosphate
Diseases			Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS		Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)	Aspartate aminotransferase levels ( 29403010) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 24097068 18193043 20864672 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Neutrophil count ( 29403010) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 28957414)
Interacting Genes		45 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 CARD9 CBY2 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 GIGYF1 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MYOG NECAB2 NOTCH2NLA PRDM14 REL SPAG5 SPRY2 TADA2A TCF4 TLE5 TMCC2 TRIM27 TRIM54 UBXN11 USHBP1 USP54 ZBTB9	4 interacting genes: EWSR1 POT1 RNF141 TERF1
Entrez ID		9470	4598
HPRD ID		05798	02015
Ensembl ID		ENSG00000135930	ENSG00000110921
Uniprot IDs		B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1	B2RDU6 B7Z301 F5H8H2 Q03426
PDB IDs		2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN	2R3V
Enriched GO Terms of Interacting Partners?
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