CD86 and TRH

Data Source:
HPRD (in vivo)

		CD86	TRH
Description		CD86 molecule	thyrotropin releasing hormone
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Centriolar Satellite Extracellular Exosome	Extracellular Region Nucleus Plasma Membrane Secretory Granule
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	Protein Binding Thyrotropin-releasing Hormone Activity
	Biological Process	Adaptive Immune Response Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway CD40 Signaling Pathway T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity	Response To Hypoxia Histamine Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Cold Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior Response To Ethanol Response To Corticosterone Negative Regulation Of Feeding Behavior
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)	Alzheimer's disease ( 30636644) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1	5 interacting genes: ARRB2 CPE KCNIP4 LCN2 TRHR
Entrez ID		942	7200
HPRD ID		03011	08944
Ensembl ID		ENSG00000114013	ENSG00000170893
Uniprot IDs		A0A0X9R4E0 A8K632 P42081	P20396
PDB IDs		1I85 1NCN 5YXK
Enriched GO Terms of Interacting Partners?
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