DNER and PDLIM7

Data Source:
BioGRID (two hybrid)

		DNER	PDLIM7
Description		delta/notch like EGF repeat containing	PDZ and LIM domain 7
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Transmembrane Signaling Receptor Activity Notch Binding Calcium Ion Binding Protein Binding Clathrin Binding	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Neuron Migration Endocytosis Notch Signaling Pathway Notch Receptor Processing Synapse Assembly Central Nervous System Development Glial Cell Differentiation Skeletal Muscle Fiber Development	Ossification Receptor-mediated Endocytosis Axon Guidance Heart Development Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Differentiation Muscle Structure Development
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus	RET signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Carotid intima media thickness x smoking interaction ( 32117412) Hand grip strength ( 29691431) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291) Type 2 diabetes ( 24101674)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: AP1G1 PDLIM7	62 interacting genes: ABI2 AP5B1 BAG3 BSG CATSPER1 CCDC185 DDX6 DGCR6 DNER ENKD1 FAM214B FAM71C FAM90A1 FNDC11 FRS3 GEM GFAP GPATCH2L HEY2 HNRNPD HNRNPF HSF2BP HSPB7 IL16 IQGAP1 KANK2 MDM2 NUDT10 OTUD6A PAK5 PARVG PCBP1 PHF1 PIN1 PLEKHN1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RASGEF1B RET RPP25 SCNM1 SH2B2 SH3BP2 SLAIN1 SMURF1 SPP1 TCF19 TNPO2 TP53 TPM2 TRAF2 TRAF3 TSG101 TSGA10IP UBE2I UBQLN4 WWP2 ZMYND11 ZNF165
Entrez ID		92737	9260
HPRD ID		09531	10436
Ensembl ID		ENSG00000187957	ENSG00000196923
Uniprot IDs		Q8NFT8	Q9NR12
PDB IDs			2Q3G
Enriched GO Terms of Interacting Partners?
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