DNER and AP1G1

Data Source:
HPRD (in vivo)

		DNER	AP1G1
Description		delta/notch like EGF repeat containing	adaptor related protein complex 1 subunit gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Transmembrane Signaling Receptor Activity Notch Binding Calcium Ion Binding Protein Binding Clathrin Binding	Protein Binding Kinesin Binding GTP-dependent Protein Binding Small GTPase Binding Clathrin Adaptor Activity Cargo Adaptor Activity
	Biological Process	Neuron Migration Endocytosis Notch Signaling Pathway Notch Receptor Processing Synapse Assembly Central Nervous System Development Glial Cell Differentiation Skeletal Muscle Fiber Development	Intracellular Protein Transport Golgi To Vacuole Transport Receptor-mediated Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Golgi To Lysosome Transport
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Carotid intima media thickness x smoking interaction ( 32117412) Hand grip strength ( 29691431) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291) Type 2 diabetes ( 24101674)	General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Post bronchodilator FEV1 ( 26634245) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		2 interacting genes: AP1G1 PDLIM7	27 interacting genes: AAGAB AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 ARFRP1 BAALC CCDC91 CLINT1 CLTC DNER EPS15 HEATR5B KIF13A MAP1A PSEN2 RABEP1 RABGEF1 SNX9 SPTB SYNRG SYP UBL7 ZNF512B
Entrez ID		92737	164
HPRD ID		09531	04637
Ensembl ID		ENSG00000187957	ENSG00000166747
Uniprot IDs		Q8NFT8	A0A140VJE7 O43747 Q8IY97
PDB IDs			1IU1
Enriched GO Terms of Interacting Partners?
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