BMP15 and GDF9

Data Source:
HPRD (in vitro)

		BMP15	GDF9
Description		bone morphogenetic protein 15	growth differentiation factor 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Lumen	Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding
	Biological Process	Ovarian Follicle Development Female Gamete Generation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Granulosa Cell Development SMAD Protein Signal Transduction	Oocyte Growth Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth BMP Signaling Pathway SMAD Protein Signal Transduction Regulation Of Progesterone Secretion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS			Asthma ( 31619474)
Interacting Genes		2 interacting genes: BMPR1B GDF9	45 interacting genes: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CDKN1A CDKN2C CRELD1 DLEU1 DNM2 FOXG1 FXYD6 GADD45G ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TDGF1 TK1 TRIB3 WASHC3
Entrez ID		9210	2661
HPRD ID		02216	03560
Ensembl ID		ENSG00000130385	ENSG00000164404
Uniprot IDs		O95972	B4DXG3 O60383
PDB IDs
Enriched GO Terms of Interacting Partners?
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