NEK9 and LIN52

Data Source:
BioGRID (proximity labelling technology)

		NEK9	LIN52
Description		NIMA related kinase 9	lin-52 DREAM MuvB core complex component
Image
GO Annotations	Cellular Component	Nucleus Centrosome Cytosol	Nucleoplasm DRM Complex
	Molecular Function	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division	Transcription, DNA-templated Regulation Of Cell Cycle
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry
Drugs		Fostamatinib
Diseases
GWAS		Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)	Blood protein levels ( 28240269) Chronotype ( 30696823) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Waist-hip ratio ( 28552196)
Interacting Genes		10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN	6 interacting genes: DYRK1A EPM2AIP1 MAGEA6 MYBL2 RBBP4 RBL2
Entrez ID		91754	91750
HPRD ID		11386	18708
Ensembl ID		ENSG00000119638	ENSG00000205659
Uniprot IDs		Q6PKF2 Q8TD19	B3KN83 Q52LA3
PDB IDs		3ZKE 3ZKF	4YOO 6C48
Enriched GO Terms of Interacting Partners?
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