ZNF804A and DUSP19

Data Source:
BioGRID (biochemical)

		ZNF804A	DUSP19
Description		zinc finger protein 804A	dual specificity phosphatase 19
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Growth Cone Neuronal Cell Body Dendritic Spine Dendritic Shaft Presynapse Postsynapse Dendritic Microtubule	Cytoplasm
	Molecular Function	Molecular_function Metal Ion Binding	Protein Tyrosine Phosphatase Activity Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Phosphatase Activity Protein Kinase Activator Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Positive Regulation Of Gene Expression Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Dendritic Spine Maintenance	Negative Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Peptidyl-tyrosine Dephosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade
Pathways
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Broad depression or schizophrenia ( 30626913) Cervical artery dissection ( 25420145) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dentures ( 31235808) Feeling hurt ( 29500382) Loneliness (linear analysis) ( 27629369) Neurociticism ( 29500382) Neuroticism ( 29255261) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Schizophrenia ( 28991256 25056061 18677311 29483656 30285260) Systolic blood pressure ( 30224653)
Interacting Genes		2 interacting genes: ATXN1 SPP1	20 interacting genes: ACTB ALAS1 ALK EGFR EPHA2 EPHB6 ERBB2 ERBB3 ERBB4 FLT4 IGF1R INSR KDR LMTK2 MAP2K7 MAP3K5 MAPK9 PTK7 ROR1 ROR2
Entrez ID		91752	142679
HPRD ID		12804	13254
Ensembl ID		ENSG00000170396	ENSG00000162999
Uniprot IDs		Q7Z570	Q8WTR2
PDB IDs			3S4E 4D3P 4D3Q 4D3R
Enriched GO Terms of Interacting Partners?
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