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KRT75 and NEK6
Data Source:
BioGRID
(two hybrid)
KRT75
NEK6
Description
keratin 75
NIMA related kinase 6
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytosol
Intermediate Filament
Keratin Filament
Extracellular Exosome
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Microtubule
Nuclear Speck
Protein-containing Complex
Centriolar Satellite
Molecular Function
Structural Molecule Activity
Protein Binding
Magnesium Ion Binding
Transcription Corepressor Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinesin Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Hematopoietic Progenitor Cell Differentiation
Keratinization
Cornification
Protein Phosphorylation
Apoptotic Process
Chromosome Segregation
Mitotic Nuclear Envelope Disassembly
Regulation Of Mitotic Cell Cycle
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Protein Autophosphorylation
Spindle Assembly
Cell Division
Regulation Of Cellular Senescence
Pathways
Keratinization
Formation of the cornified envelope
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
Pseudofolliculitis barbae
GWAS
Asthma (
32296059
)
Asthma exacerbations in inhaled corticosteroid treatment (
30697902
)
Blond vs. brown/black hair color (
30531825
)
Chronotype (
30696823
)
Cognitive performance (
20125193
)
Free thyroxine concentration (
30367059
)
Heel bone mineral density (
30598549
)
Medication use (thyroid preparations) (
31015401
)
Mercury levels (
26025379
)
Neurociticism (
29500382
)
Pulse pressure (
30224653
)
Thyroid stimulating hormone levels (
32769997
)
Vitiligo (
27723757
)
Interacting Genes
124 interacting genes:
ABI2
AMOT
ANKS1A
ARMC7
ASB15
BCAS2
BEX2
C19orf25
C1orf109
C1orf216
C2CD6
CAMK2A
CARD10
CARD9
CCDC102B
CCDC197
CCHCR1
CDC37
CDK18
CDKN2D
CEP57
CFAP206
CPNE7
CRACR2A
DES
DHX15
DMAP1
DTNBP1
DYDC1
EFHC1
EPM2AIP1
FBXO17
FKBP6
GLYCTK
GMCL1
GOLGA2
GOLGA6L9
GPANK1
HGS
HNRNPF
INCA1
IQUB
KANK2
KCTD7
KIF9
KIFC3
KRT13
KRT15
KRT19
KRT20
KRT24
KRT25
KRT26
KRT27
KRT3
KRT31
KRT33B
KRT34
KRT35
KRT36
KRT37
KRT38
KRT40
KRT76
LCA5L
LMO1
LMO2
LMO4
LONRF1
MAGOHB
MID2
MKRN3
MNS1
MTUS2
MYO15B
MYOZ3
NCDN
NDC80
NEK6
NFKBID
NME7
NUDT21
NUP62
OIP5
OSGIN1
PLEKHG4
PM20D2
POLR1C
POLR3C
PRPH
RCOR3
RSPH14
SCNM1
SMARCD1
SPAG5
SPTA1
STX11
SUFU
TBC1D1
TCHP
TEKT1
TEKT4
TJAP1
TNPO2
TNPO3
TRAF1
TRIM23
TRIM27
TRIM54
TRIML2
TSG101
TSSK3
TXLNA
TXLNB
U2AF1
U2AF1L5
USHBP1
VIM
WASHC1
WASHC3
WWOX
XPOT
ZNF76
ZWINT
117 interacting genes:
ANKRA2
ARHGAP33
ARRB1
ATF4
BEND7
BHLHE40
CBY2
CCDC120
CCDC136
CCDC85B
CDC42
CDK7
CEP76
CFP
CIR1
COG6
CTBP2
DDIT4L
DES
DPH2
EFHC2
ERCC6L2
FAM220A
FHL5
FOXJ3
GFAP
GIGYF1
GLIS3
GOLGA6L2
GRIP1
HOMEZ
HOOK2
HOXA1
HOXB6
HSD17B14
IHO1
IKZF1
IKZF3
INCA1
KATNBL1
KCTD5
KIAA1328
KRT31
KRT34
KRT40
KRT75
KRT8
KRTAP10-8
KRTAP13-1
KRTAP13-3
LNX1
LZTS1
LZTS2
MBD3L1
MEOX2
METTL15
MYOG
MYOZ3
NECAB2
NEFL
NEK9
NIF3L1
NUDT16L1
PAK6
PBX4
PHF1
PICK1
PIN1
PLEKHA7
PPP1R16A
PRAM1
PRDM16
PRDM6
PRDX3
PRICKLE4
PTN
PTPN21
PTPRD
RBAK
RBBP6
RIMBP3C
RPS6KB1
RPS7
SAXO1
SGK1
SH3RF2
SMAD4
SMUG1
SMURF2
SORBS3
SPRY3
TASOR2
TCF12
TCF4
TEPSIN
TEX45
TFIP11
TGFBR1
TLE5
TNK2
TRAF2
TRIM23
TRIM27
TRIM54
TRIP4
UBXN11
XIAP
ZC2HC1C
ZCCHC7
ZFP90
ZNF24
ZNF343
ZNF438
ZNF587
ZNF688
ZNF774
ZRANB1
Entrez ID
9119
10783
HPRD ID
11057
05348
Ensembl ID
ENSG00000170454
ENSG00000119408
Uniprot IDs
O95678
A0A024R8A6
Q9HC98
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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