KLC4 and PKP2

Data Source:
BioGRID (two hybrid)

		KLC4	PKP2
Description		kinesin light chain 4	plakophilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Kinesin Complex Microtubule	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process		Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Keratinization Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Cornification Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Keratinization Formation of the cornified envelope
Drugs
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Hemoglobin levels ( 32327693)	Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 32201043 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)
Interacting Genes		32 interacting genes: ABI3 AKAP9 APP CASK CEP57 CEP57L1 COIL DDX6 KATNAL1 KLC2 KPNA2 KRT13 KRT15 KRT16 KRT31 KRT33B KRT34 MEOX2 NDEL1 NECAB2 PCM1 PDE4DIP PKP2 PRC1 RBM14 SERTAD1 SLC16A9 TADA2A USHBP1 YWHAE YWHAZ ZNF343	40 interacting genes: ACTN3 AKAP9 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 ROPN1 SMAD9 SPTA1 TEKT4 YWHAG
Entrez ID		89953	5318
HPRD ID		13932	04177
Ensembl ID		ENSG00000137171	ENSG00000057294
Uniprot IDs		A0A024RCZ8 Q9NSK0	Q99959
PDB IDs			3TT9
Enriched GO Terms of Interacting Partners?
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