CACNA1H and PAK6

Data Source:
BioGRID (biochemical)

		CACNA1H	PAK6
Description		calcium voltage-gated channel subunit alpha1 H	p21 (RAC1) activated kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Neuron Projection	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Muscle Contraction Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Neuronal Action Potential Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Biosynthetic Process Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Regulation Of Membrane Potential Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Inorganic Cation Transmembrane Transport Positive Regulation Of Acrosome Reaction	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Neuron Projection Arborization Neuron Projection Extension
Pathways		NCAM1 interactions	Activation of RAC1
Drugs		Ergocalciferol Enflurane Isradipine Spironolactone Cinnarizine Verapamil Zonisamide Felodipine Nitrendipine Nifedipine Bepridil Mibefradil Flunarizine Cannabidiol Trimebutine Benidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols	Fostamatinib
Diseases
GWAS		Blood protein levels ( 28240269) Eosinophil counts ( 32888494) Leukocyte telomere length ( 32109421)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		3 interacting genes: CCR4 GNG2 KCNMA1	20 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 TPD52L1
Entrez ID		8912	56924
HPRD ID		07442	06426
Ensembl ID		ENSG00000196557	ENSG00000137843
Uniprot IDs		A0A1W2PQW2 B3KQH9 O95180	A0A024R9Q4 Q9NQU5
PDB IDs			2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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