Wiki-Pi
About
Search
Browse
People
Updates
Search
CDK5R1 and SUZ12
Data Source:
BioGRID
(affinity chromatography technology)
CDK5R1
SUZ12
Description
cyclin dependent kinase 5 regulatory subunit 1
SUZ12 polycomb repressive complex 2 subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Perikaryon
Intracellular Membrane-bounded Organelle
Contractile Fiber
Perinuclear Region Of Cytoplasm
Presynapse
Nucleus
Nucleoplasm
Nucleolus
Nuclear Body
ESC/E(Z) Complex
Molecular Function
Protease Binding
Protein Kinase Activity
Calcium Ion Binding
Protein Binding
Kinase Activity
Protein Kinase Binding
Protein Kinase Activator Activity
Ionotropic Glutamate Receptor Binding
Alpha-tubulin Binding
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
Ephrin Receptor Binding
Beta-tubulin Binding
Actin Filament Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
RNA Polymerase II Transcription Corepressor Binding
Protein Binding
Chromatin DNA Binding
Methylated Histone Binding
Histone Methyltransferase Activity
Metal Ion Binding
Histone Methyltransferase Activity (H3-K27 Specific)
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Microtubule Cytoskeleton Organization
Neuron Migration
Neuron Cell-cell Adhesion
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Axon Guidance
Axonal Fasciculation
Brain Development
Embryo Development Ending In Birth Or Egg Hatching
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cerebellum Development
Superior Olivary Nucleus Maturation
Hippocampus Development
Layer Formation In Cerebral Cortex
Neuron Differentiation
Negative Regulation Of Axon Extension
Positive Regulation Of Microtubule Polymerization
Neuron Projection Development
Activation Of Protein Kinase Activity
Regulation Of Actin Cytoskeleton Organization
Ionotropic Glutamate Receptor Signaling Pathway
Serine Phosphorylation Of STAT Protein
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Ephrin Receptor Signaling Pathway
Rhythmic Process
Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Synaptic Vesicle Cycle
Regulation Of Signal Transduction By P53 Class Mediator
Spinal Cord Development
Response To Retinoic Acid
Negative Regulation Of Chemokine Production
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Cell Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of G0 To G1 Transition
Histone H3-K27 Trimethylation
Pathways
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
SUMOylation of chromatin organization proteins
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
HCMV Early Events
Drugs
Indirubin-3'-monoxime
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
High chromosomal aberration frequency (chromosome type) (
31586183
)
Hip circumference adjusted for BMI (
25673412
)
Interacting Genes
31 interacting genes:
ACTN1
AMPH
APP
BLOC1S6
CAMK2A
CAPN1
CAPN2
CDK16
CDK5
CDK5RAP1
CDK5RAP2
CDK5RAP3
CDK9
CHN1
CTNNB1
HSP90AA1
KRT40
KRTAP10-3
LMTK2
MTUS2
NEDD4
NES
NOTCH2NLA
ODF1
PAK1
SEPTIN5
SET
SIAH1
STXBP1
TSC22D4
TTBK1
17 interacting genes:
AEBP2
BCL11A
CDK19
CDK8
CREB1
CTCF
EZH2
H1-1
H3-4
LATS2
MED17
MED6
PAXIP1
PJA1
PRDM14
UBE2I
WDR77
Entrez ID
8851
23512
HPRD ID
04586
06949
Ensembl ID
ENSG00000176749
ENSG00000178691
Uniprot IDs
Q15078
Q8N619
J3QQW9
Q15022
PDB IDs
1H4L
1UNG
1UNH
1UNL
3O0G
6LDP
7CNG
4W2R
5HYN
5IJ7
5IJ8
5LS6
5WAI
5WAK
5WG6
6B3W
6C23
6C24
6NQ3
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?