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KAT2B and SIRT2
Data Source:
HPRD
(in vivo)
KAT2B
SIRT2
Description
lysine acetyltransferase 2B
sirtuin 2
Image
GO Annotations
Cellular Component
PCAF Complex
Kinetochore
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Centrosome
Cytosol
A Band
I Band
Protein-containing Complex
Actomyosin
Chromosome, Telomeric Region
Heterochromatin
Nucleus
Chromatin Silencing Complex
Chromosome
Nucleolus
Cytoplasm
Mitochondrion
Centrosome
Centriole
Spindle
Cytosol
Microtubule
Plasma Membrane
Growth Cone
Midbody
Paranodal Junction
Paranode Region Of Axon
Perikaryon
Myelin Sheath
Lateral Loop
Schmidt-Lanterman Incisure
Juxtaparanode Region Of Axon
Perinuclear Region Of Cytoplasm
Mitotic Spindle
Meiotic Spindle
Glial Cell Projection
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Diamine N-acetyltransferase Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Acetyltransferase Activity
Protein Kinase Binding
Histone Deacetylase Binding
Peptide-lysine-N-acetyltransferase Activity
Chromatin Binding
NAD+ ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
NAD-dependent Histone Deacetylase Activity
Protein Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
Histone Acetyltransferase Binding
Histone Deacetylase Binding
Tubulin Deacetylase Activity
Ubiquitin Binding
NAD-dependent Histone Deacetylase Activity (H4-K16 Specific)
NAD+ Binding
Biological Process
Chromatin Remodeling
Transcription Initiation From RNA Polymerase II Promoter
Protein Acetylation
Cell Cycle Arrest
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Heart Development
Negative Regulation Of Cell Population Proliferation
Regulation Of Protein ADP-ribosylation
Viral Process
Protein Deubiquitination
N-terminal Peptidyl-lysine Acetylation
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Cellular Response To Insulin Stimulus
Histone H3 Acetylation
Histone H3-K9 Acetylation
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Rhythmic Process
Limb Development
Negative Regulation Of RRNA Processing
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Assembly
Chromatin Silencing
Chromatin Silencing At Telomere
Protein ADP-ribosylation
Protein Deacetylation
Autophagy
Regulation Of Exit From Mitosis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Autophagy
Negative Regulation Of Peptidyl-threonine Phosphorylation
Phosphatidylinositol 3-kinase Signaling
Histone Deacetylation
Substantia Nigra Development
Myelination In Peripheral Nervous System
Regulation Of Myelination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Oxidative Stress
Peptidyl-lysine Deacetylation
Cellular Response To Hepatocyte Growth Factor Stimulus
Negative Regulation Of Protein Catabolic Process
Regulation Of Phosphorylation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Binding
Protein Kinase B Signaling
Cellular Lipid Catabolic Process
Innate Immune Response
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Meiotic Nuclear Division
Negative Regulation Of Striated Muscle Tissue Development
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Cell Division
Meiotic Cell Cycle
Regulation Of Cell Cycle
Response To Redox State
Positive Regulation Of Cell Division
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Caloric Restriction
Negative Regulation Of Oligodendrocyte Progenitor Proliferation
Histone H3 Deacetylation
Histone H4 Deacetylation
Cellular Response To Molecule Of Bacterial Origin
Cellular Response To Hypoxia
Cellular Response To Epinephrine Stimulus
Tubulin Deacetylation
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Oocyte Maturation
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Negative Regulation Of Defense Response To Bacterium
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Physiological factors
Metalloprotease DUBs
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
Regulation of FOXO transcriptional activity by acetylation
Initiation of Nuclear Envelope (NE) Reformation
Drugs
Coenzyme A
(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Cambinol
Diseases
GWAS
Drug abuse (
26202629
)
High light scatter reticulocyte count (
32888494
)
Mean arterial pressure (alcohol consumption interaction) (
24376456
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
29403010
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Optic disc size (
31809533
)
Post-traumatic stress disorder (
24677629
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Staphylococcus aureus nasal carriage (intermittent) (
26569114
)
Systolic blood pressure (
30224653
30578418
)
Interacting Genes
121 interacting genes:
ACTN1
ACTN2
AKT1
AR
ARHGDIA
ARNTL
ATF4
ATXN3
BRCA2
CCNA2
CCND1
CCNT1
CDC25B
CDCA4
CDK2
CDKN1B
CDT1
CEBPB
CEP250
CIITA
CLOCK
CREBBP
CTBP1
CTNNB1
CUX1
DACH2
DEK
EP300
ESRRA
ETV1
EZH2
GATAD2A
GATAD2B
H1-1
H1-5
H2AC20
H2AC4
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4-16
H4C1
HIPK2
HMGA1
HMGN2
HNF1A
HNRNPU
HOXB9
HSD11B2
HTT
ING1
IRF1
IRF2
IRF7
JDP2
KLF10
KLF13
KLF2
LIN28B
MAPK14
MAPRE1
MDM2
MECOM
MYC
MYOD1
NCOA1
NCOA3
NCOA4
NFATC1
NFE2
NFE4
NOTCH1
NOTCH3
NPAS2
NR1H3
NR4A1
NRIP1
ONECUT1
PARP1
PDK1
PGR
PLAGL1
PNMA1
POLR2A
PTF1A
RAB11A
RARA
RB1
RBM8A
RBPJ
RELA
RPS6KB1
RPS6KB2
SAT2
SATB1
SERBP1
SERTAD1
SERTAD2
SIRT2
SMAD1
SMAD2
SMAD3
SRCAP
TACC2
TAL1
TCF3
TMF1
TP53
TP63
TP73
TRIM14
TTF1
TWIST1
UBE2D1
UBE2D2
UBE2D3
XRCC6
YY1
19 interacting genes:
ARHGDIA
CDC14B
CDC20
CDK2
EP300
FZR1
H3C1
HDAC6
HIF1A
HOXA10
KAT2A
KAT2B
MDM2
OXTR
PLA2G4A
RAD51
SP140
TUBA4A
XPO1
Entrez ID
8850
22933
HPRD ID
06780
10377
Ensembl ID
ENSG00000114166
ENSG00000068903
Uniprot IDs
Q92831
A0A024R0G8
A0A0A0MRF5
Q8IXJ6
PDB IDs
1CM0
1JM4
1N72
1WUG
1WUM
1ZS5
2RNW
2RNX
3GG3
4NSQ
5FDZ
5FE0
5FE1
5FE2
5FE3
5FE4
5FE5
5FE6
5FE7
5FE8
5FE9
5LVQ
5LVR
5MKX
6J3O
1J8F
3ZGO
3ZGV
4L3O
4R8M
4RMG
4RMH
4RMI
4RMJ
4X3O
4X3P
4Y6L
4Y6O
4Y6Q
5D7O
5D7P
5D7Q
5DY4
5DY5
5FYQ
5G4C
5MAR
5MAT
5Y0Z
5Y5N
5YQL
5YQM
5YQN
5YQO
6L65
6L66
6NR0
6QCN
Enriched GO Terms of Interacting Partners
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