TNFSF9 and KHSRP

Data Source:
BioGRID (affinity chromatography technology)

		TNFSF9	KHSRP
Description		TNF superfamily member 9	KH-type splicing regulatory protein
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor Receptor Superfamily Binding	DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Immune Response Cell-cell Signaling Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Cytotoxic T Cell Differentiation	RNA Splicing, Via Transesterification Reactions Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Gene Expression MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus
Pathways		TNFs bind their physiological receptors	ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs			Resveratrol Artenimol
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: TNFRSF9 TRAF1 TRAF2	14 interacting genes: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 KLHL12 PARN PTBP2 STK3 UBE2I
Entrez ID		8744	8570
HPRD ID		05861	10350
Ensembl ID		ENSG00000125657	ENSG00000088247
Uniprot IDs		A0A0U5J8I0 P41273	Q92945
PDB IDs		2X29 6A3V 6BWV 6CPR 6CU0 6D3N 6FIB 6MGE 6MGP	2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T
Enriched GO Terms of Interacting Partners?
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