TNFSF11 and PRXL2B

Data Source:
BioGRID (two hybrid)

		TNFSF11	PRXL2B
Description		TNF superfamily member 11	peroxiredoxin like 2B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Endoplasmic Reticulum Cytosol Myelin Sheath Extracellular Exosome
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding	Protein Binding Antioxidant Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Prostaglandin-F Synthase Activity
	Biological Process	Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Activation Of JUN Kinase Activity Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Osteoclast Development Paracrine Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Tooth Eruption Bone Resorption Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Protein Kinase B Signaling Calcium Ion Homeostasis Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Actin Binding Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Osteoclast Development	Prostaglandin Biosynthetic Process Cellular Oxidant Detoxification
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Lenalidomide AMGN-0007 Denosumab Thiocolchicoside
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Arthritis (juvenile idiopathic) ( 33106285) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740 23437003) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) C-reactive protein levels ( 24763700) Cortical thickness ( 22792071) Crohn's disease ( 21102463) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Serum alkaline phosphatase levels ( 29403010) Vitiligo ( 27723757)
Interacting Genes		32 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA OLFM4 PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A UPK2 ZC3HC1	4 interacting genes: COPS3 PDPK1 TCP11L1 TNFSF11
Entrez ID		8600	127281
HPRD ID		04031	14513
Ensembl ID		ENSG00000120659	ENSG00000157870
Uniprot IDs		O14788 Q54A98 Q5T9Y4	A0A0A0MRV4 A0A0A0MT35 A0A2P0CTB1 A0A2P0CU24 Q8TBF2
PDB IDs		3URF 5BNQ
Enriched GO Terms of Interacting Partners?
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