TANC1 and SHANK1

Data Source:
HPRD (in vitro)

		TANC1	SHANK1
Description		tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	SH3 and multiple ankyrin repeat domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Postsynaptic Density Dendrite Neuronal Cell Body Axon Terminus	Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse
	Molecular Function	Protein Binding	Protein Binding Protein C-terminus Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding
	Biological Process	Myoblast Fusion Visual Learning Dendritic Spine Maintenance	Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Nicotine dependence ( 28440896) Night sleep phenotypes ( 27126917) Response to radiotherapy in prostate cancer (toxicity) ( 24974847) Resting heart rate ( 27798624) Restless legs syndrome ( 29029846) Tourette syndrome ( 30818990)	Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		12 interacting genes: ACTB CAMK2A CASK DLG1 DLG4 DLGAP1 GRIA1 GRIN2B HOMER1 INA SHANK1 SPTAN1	19 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8
Entrez ID		85461	50944
HPRD ID		18146	05413
Ensembl ID		ENSG00000115183	ENSG00000161681
Uniprot IDs		B9EK39 Q9C0D5	H9KV90 Q9Y566
PDB IDs			6CPI
Enriched GO Terms of Interacting Partners?
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