SPIRE2 and IRF8

Data Source:
BioGRID (x-ray crystallography)

		SPIRE2	IRF8
Description		spire type actin nucleation factor 2	interferon regulatory factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Cell Cortex Cytoplasmic Vesicle Membrane Cleavage Furrow	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Actin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Actin Cytoskeleton Organization Actin Filament Polymerization Cleavage Furrow Formation Polar Body Extrusion After Meiotic Divisions Actin Nucleation Intracellular Transport Golgi Vesicle Transport Establishment Of Meiotic Spindle Localization Actin Filament Network Formation Formin-nucleated Actin Cable Assembly Positive Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Immune System Process Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Transcription By RNA Polymerase II Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Dendritic Cell Differentiation
Pathways			Interferon gamma signaling Interferon alpha/beta signaling
Drugs		Latrunculin B
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Low tan response ( 29739929) Mean reticulocyte volume ( 32888494) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Red vs. brown/black hair color ( 30531825) White matter integrity (fractional anisotropy) ( 32358547)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 21131588 28165464 26956414 24292274 23770605) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Diabetic retinopathy ( 21441570) Gestational age at birth (maternal effect) ( 27490719) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233) Limited cutaneous systemic scleroderma ( 29293537) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23857890) Monocyte count ( 23314186 28193307 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 24076602 19525953 21833088) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26663301 26502338 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020) Ulcerative colitis ( 32072174 23511034)
Interacting Genes		1 interacting genes: HGS	12 interacting genes: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17
Entrez ID		84501	3394
HPRD ID		18099	03336
Ensembl ID		ENSG00000204991	ENSG00000140968
Uniprot IDs		Q8WWL2	Q02556
PDB IDs		5JCY
Enriched GO Terms of Interacting Partners?
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