ANKRD27 and RAB40B

Data Source:
BioGRID (two hybrid)

		ANKRD27	RAB40B
Description		ankyrin repeat domain 27	RAB40B, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Early Endosome Late Endosome Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Melanosome Neuron Projection Tubular Endosome	Nuclear Envelope Endosome Plasma Membrane Synaptic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	SNARE Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Positive Regulation Of Neuron Projection Development Protein Transport Negative Regulation Of SNARE Complex Assembly Endosome To Melanosome Transport Positive Regulation Of GTPase Activity Early Endosome To Late Endosome Transport Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Retrograde Transport, Endosome To Plasma Membrane	Protein Ubiquitination Intracellular Signal Transduction Protein Localization To Plasma Membrane Toxin Transport
Pathways		RAB GEFs exchange GTP for GDP on RABs	RAB geranylgeranylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Eosinophilic esophagitis ( 25407941) Gut microbiota relative abundance (Bacteroides) ( 33208821) Major depressive disorder ( 23377640) Red cell distribution width ( 27863252 28957414) Systemic lupus erythematosus ( 33536424)	Colorectal cancer or advanced adenoma ( 30510241)
Interacting Genes		5 interacting genes: RAB40A RAB40B RAB40C SMAD1 VAMP7	6 interacting genes: ANKRD27 APP EFEMP2 FHIT FHL3 WFDC1
Entrez ID		84079	10966
HPRD ID		10650	11472
Ensembl ID		ENSG00000105186	ENSG00000141542
Uniprot IDs		Q96NW4	Q12829
PDB IDs		4B93 4CYM 4CZ2 6TL0
Enriched GO Terms of Interacting Partners?
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