EPPK1 and STK4

Data Source:
BioGRID (affinity chromatography technology)

		EPPK1	STK4
Description		epiplakin 1	serine/threonine kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Cell Junction Hemidesmosome Cell Projection Keratin Filament Cell Periphery Perinucleolar Compartment	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	RNA Binding Structural Molecule Activity Intermediate Filament Binding Keratin Filament Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Cell Migration Wound Healing Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Bundle Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Keratinocyte Migration Negative Regulation Of Wound Healing Regulation Of Epithelium Regeneration	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS		Knee osteoarthritis ( 28916551) Multiple sclerosis ( 31604244)	Bipolar disorder ( 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		3 interacting genes: EGFR SUMO2 UCHL5	23 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 IL2RG KEAP1 LATS1 MARK2 MBP NEDD4 PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 STK3 THAP12 TP53
Entrez ID		83481	6789
HPRD ID		06500	05395
Ensembl ID		ENSG00000261150	ENSG00000101109
Uniprot IDs		P58107	Q13043
PDB IDs			2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT
Enriched GO Terms of Interacting Partners?
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