PMFBP1 and MLKL

Data Source:
BioGRID (affinity chromatography technology)

		PMFBP1	MLKL
Description		polyamine modulated factor 1 binding protein 1	mixed lineage kinase domain like pseudokinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Sperm Connecting Piece	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Junction
	Molecular Function	Molecular_function	Protein Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding
	Biological Process	Spermatogenesis	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Activation Of JNKK Activity Activation Of JUN Kinase Activity Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis
Pathways			TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 28240269) Body mass index (change over time) in cancer ( 28044437) Body mass index (change over time) in cancer or chronic obstructive pulmonary disease ( 28044437) Chronotype ( 30696823) Depression ( 29700475) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 31217584) Lung function (FVC) ( 30061609) Mean reticulocyte volume ( 32888494) Morning person ( 30696823) Offspring birth weight ( 31043758) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 31666285) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 31217584) Triglyceride levels ( 32203549)	Testicular germ cell tumor ( 23666239)
Interacting Genes			7 interacting genes: ANAPC11 CDK1 NDUFB7 PSMB1 RAD18 S100A10 THOC3
Entrez ID		83449	197259
HPRD ID		10157	08752
Ensembl ID		ENSG00000118557	ENSG00000168404
Uniprot IDs		Q8TBY8	Q8NB16
PDB IDs			2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6O5Z 6UX8
Enriched GO Terms of Interacting Partners?
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